Seasonal Affective Disorder Network (SADnet)


Iron Mill News Service


 Diurnal and seasonal rhythms of melatonin, cortisol and testosterone in interior Alaska.

Levine ME, Milliron AN, Duffy LK.

Community Mental Health Services, Ft. Wainwright, Alaska.

The diurnal variations in the secretory patterns of melatonin, cortisol and testosterone were studied in a Fairbanks, Alaska population who were unadapted to the extreme light variations of the North. Statistically significant variations in hormonal levels were found in both diurnal and seasonal rhythms. Prominent findings included unusually high levels of cortisol at 0200 and 0800 in the fall and elevated daytime levels (1030) of melatonin in the winter. These results indicate a delayed phase secretory pattern when compared to the normal pattern at lower latitudes. These findings imply possible underlying physiological causes for the high incidence of behavior disorders such as depression and alcoholism in Alaska and circumpolar environments in general.

PMID: 8048998 PubMed - indexed for MEDLINE

For the Full Text of this Article Please click Here


 SADnet Links

 
Society for Light Treatment & Biological Rhythms 
Aimed at professionals, encourages research and clinical development in light therapy and biological rhythms.
MedlinePlus: Seasonal Affective Disorder
Links to websites and organizations dealing with SAD.
Seasonal Affective Disorder Association
Information and membership details for the SAD Association (SADA), based in the UK.
Brighten Your Life
An online book by a psychiatrist about bright light therapy for depression and sleep.
Seasonal Affective Disorder 
NMHA fact sheet describing symptoms and treatment for this affective disorder.
Norman E. Rosenthal 
Psychiatrist pioneering in SAD research presents articles, personal comments, and mentions of his books.
Seasonal Affective Disorder 
Journal article about SAD details its diagnosis, symptoms, epidemiology, and light therapy.
Center for Environmental Therapuetics
Environmental treatments (ie. light therapy) for SAD and other disorders are detailed.
Seasonal Affective Disorders
In depth, clinical discussion of SAD, including references (American Academy of Family Physicians).
Seasonal Affective Disorder: Winter Depression - http://www.ncpamd.com/seasonal.htm
Discusses the diagnosis and treatment of SAD and related mood and sleep problems.
NOSAD Information on Combating Seasonal Depression 
Basic fact sheet from the National Organization for SAD.
Seasonal Depression and Light Therapy 
Article from the UK's National Institute for Medical Research.
Dawn's Early Light to Twilight's Last Gleaming
JAMA article on SAD and light treatment. Also mentions other possible applications.
Light Therapy – Procedure for Using the 10,000 Lux Fluorescent Light Box 
From a university psychiatry department.
Overcoming SAD 
An interview with SAD researcher Norman Rosenthal, MD (WebMD).


Cited in Publication

NeuroReport - Fulltext: Volume 12(6) May 8, 2001 p 1277-1280
 Melatonin acts as antioxidant and pro-oxidant in an organotypic slice
Levine ME, Milliron AN, Duffy LK. et al. Arct Med Res (1994) 53, 25-34. .


Am. J. Epidemiol. -- Erren et al. 154 (10): 977
 Medline]; Levine ME, Milliron AN, Duffy LK. Diurnal and seasonal rhythms of
melatonin,  [Abstract/Free Full Text]; Stevens RG, Davis S. The melatonin

Diurnal and seasonal rhythms of melatonin, cortisol and
 Levine ME, Milliron AN, Duffy LK. Community Mental Health Services, Ft.
Wainwright,  The diurnal variations in the secretory patterns of melatonin,

[PDF] Alcoholic Typology and Season of Birth
File Format: PDF/Adobe Acrobat
 Matthew E. Levine, MD. Barbara E. Wojcik, PhD. ABSTRACT.  Levine ME, Milliron
AN, Duffy LK. Diurnal and seasonal rhythms of melato-
 

[PDF] Circumpolar 62.3/03
File Format: PDF/Adobe Acrobat - View as HTML
 Levine ME,Milliron AN,Duffy LK,Diurnal and sea-. sonal rhythms of melatonin,cortisol
and testostero-. ne in interior Alaska.Arctic Med Res 1994;53:25-34
 

[PDF] Urinary 6-sulfatoxymelatonin excretion in humans during domestic
File Format: PDF/Adobe Acrobat
 addressing the hypothesis of disturbances in melatonin secretion as a plausible
 13 Levine ME, Milliron AN, Duffy LK. Diurnal and seasonal rhythms
 

Variation in Levels of Serum Inhibin B, Testosterone, Estradiol
 Eur J Endocrinol 131:263–272[Medline]; Levine ME, Milliron AN, Duffy LK 1994
Diurnal and seasonal rhythms of melatonin, cortisol and testosterone in
j

Send your questions to concepts@milliron.net